Small Sample Research Designs for Evidence-based Rehabilitation: Issues and Methods PMC

Table Of Content

• NDesigns is a Tennessee-based company serving customers from New York to Japan.
• Small Sample Research Designs for Evidence-based Rehabilitation: Issues and Methods
• Changing Intensity and Alternating Treatments Designs
• N logos not a good fit? Try something else:
• Opportunities and Challenges for Small-N Designs in Rehabilitation

However, it is important to recognize that the bimodality is not at the level of the data but at the level of the parameters of the cognitive model that generated the data. How that bimodality is expressed at the level of the data will depend on a transformation (usually nonlinear, e.g., Eqs. A2 and A3) that expresses the value of the parameter in the observed data. The qualitative expression of bimodality at the level of empirical measurement is merely that some participants display convincing evidence of an interaction while others display weak or no evidence.

NDesigns is a Tennessee-based company serving customers from New York to Japan.

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Small Sample Research Designs for Evidence-based Rehabilitation: Issues and Methods

Collectively, these methods represent an established and sophisticated way of doing scientific psychology that is very different in style and substance to the one targeted by the OSC’s replication study and characterized as inherently flawed by the scientific and popular press. When the goal is to estimate population parameters, when the phenomenon of interest is highly reactive (i.e., changed by observation), and when only limited data can be collected from individuals, then the recommendation to increase sample size at the participant level is an appropriate one. To foreshadow the contents of the rest of the article, our primary aim is not to denigrate current research practices, but, rather, to provide a sharper and more balanced appraisal of what we believe are the often-overlooked merits of small-N designs. These designs concentrate their experimental power at the individual participant level and provide high-powered tests of effects at that level. As a result, they are in a sense automatically “self-replicating” (Little & Smith, 2018), as we discuss more fully later. In addition to their self-replicating properties, small-N studies often embody a number of hallmarks of good scientific practice, particularly as they pertain to precise measurement, effective experimental control, and quantitatively exact theory.

Changing Intensity and Alternating Treatments Designs

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Because the occurrence, sign, and magnitude of such interactions depend on the durations of all of the stages comprising the network, interactions are more common and individual differences in interaction become more plausible than they are in a pure additive factors framework. Some of the same qualities that make RCTs the gold-standard for efficacy research may limit their application in assessing the effectiveness of a given intervention for an individual patient. Effectiveness studies are designed to examine the effects of an intervention with typical patients in everyday situations wherein an investigator cannot control all the extraneous factors. RCTs tend to have strict inclusion and exclusion criteria and typically report average treatment effects obtained from statistical comparisons of group-level (aggregate) data from experimental and control groups.

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N logos not a good fit? Try something else:

On the one hand, one of the most well-known examples of aggregation artifact is that of learning curves (Estes, 1956; Gallistel et al., 2004; Sidman, 1960). As has long been recognized, averaging a family of discontinuous learning curves of the kind produced by insight-based, all-or-none learning in which the insight point occurs at different times can produce a smoothly increasing group curve of the kind predicted by incremental-learning, linear operator models (Batchelder, 1975). That is, the conclusions one would draw at the group and individual levels are diametrically opposed. Zealously averaging over unknown individual differences can produce results that potentially misdirect the theoretical direction of the entire field. In a recent survey of the role of small-N designs in psychology, Saville and Buskist (2003) pointed out that the use of large-N designs is a comparatively recent phenomenon, which they linked to the publication of R.

We resimulated the set of N participants 100 times allowing δ to equal 1 with a probability of [.10,.25,.50,.75,.90]. That is, 20 new simulated data sets were taken at each level of δ and then bootstrapped with the individual and group level analyses applied to each bootstrapped sample. The bootstrapping procedure was repeated 1000 times per set of simulated participants. In situations of this kind, the logic of small-N and large-N scientific discovery will unfold very differently.

Opportunities and Challenges for Small-N Designs in Rehabilitation

Although there is no necessary connection between the use of small-N designs and these other features of scientific practice, many researchers who engage in highly quantitative psychological science often favor small-N designs because they see them as possessing distinct advantages. Part of our aim is to argue that the focus on sample size as the sole or even the primary cause of unreliable psychological knowledge is to lose sight of much of what makes good science. Parenthetically, we note that while we frequently contrast small-N and large-N designs for expository purposes we really view them as ends of a continuum and, for many researchers, the methodological sweet spot may lie somewhere in between (see e.g., Rouder and Haaf (in press)). The small-N research approach includes a wide variety of designs, similar to the diversity in larger-N group comparison designs.

Lest one think it problematic that the near-zero results are significant some proportion of the time for the individual analysis, recall that the individual analysis provides an estimate of the interaction for each participant. Consequently, one can examine the value of the estimate to determine its importance rather than relying on a null hypothesis test to decide whether it is or is not actually zero. In small-N designs the individual participant is the unit of analysis with each person serving as his or her own control.

The large-N approach would be to run a big sample of participants who, because of resourcing constraints, are likely at best to be minimally practiced on the task and, consequently, highly variable. After a few iterations, the field as a whole will conclude that the effect is somewhat fragile, requires large resources to demonstrate reliably, and is therefore uninteresting theoretically, and will move on to study something else. By contrast, the group analysis is only showing comparable power when all four of the simulated participants show a positive interaction. When any of the participants in the group is sampled from the null interaction effect, the power of the analysis drops substantially (from near 1.0 to .3). The implication is that the group-level analysis is masking the individual differences in the presentation of the interaction. When half or fewer of the participants show the interaction, the group-level analysis only very rarely detects an interaction.

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